Disadvantageous Resistant / Immunity?

[JCurwen3]

Resistant (and it's highest level, Immunity) is an advantage.

But what about disadvantageous Resistance / Immunity? For instance, having Immunity to Antibiotics or Immunity to Anti-Toxins. Immunity to Pain-Killers might be considered only controversially disadvantageous because they can cause euphoria and be addictive, but they can eliminate penalties due to pain. Immunity to General Anaesthesia could at some point put you in a position to need to be forcibly knocked out with blunt force head trauma (often repeatedly) or face one or more Fright Checks (with failure risking long-term mental problems) and perhaps put the successful outcome of a tricky life-saving surgery at risk. By the way, in real life 10% of people under general anaesthesia become at least partially aware during surgery; 10% of them become fully aware - and they can't scream or inform the doctors because the general anaesthesia is generally administered with drugs that paralyze the muscles so you won't involuntarily move whilst (hopefully) unconscious. And it screws some of those people up big time - Nightmares, Flashbacks, we're talking full on severe post-traumatic stress disorder in some cases.

And then we have the trickier cases. For instance, someone might have a disadvantage with a Mitigator - and then he gets Afflicted with an Immunity to that Mitigator (long enough for it to be an issue). Or worse, Immunity to the substance that must be consumed by someone with a Dependency.

Not sure how to do that or of appropriate pricing.