Rearranging the setting.

[Astromancer]

This thread is about taking the Transhuman Space setting is switched up in some way or other. Example: It's hinted in both the 3ed and 4th eds of GURPS:BIO-TECH that there was a post apocolyptic setting about 50 years into the future of the setting. It was a rationalised Gama World slanted toward gothic-horror and action movie violence. Certainly a different world.

Another setting might involve one of the powers having conquered the Earth and forcing everything into their chosen mold. Forcing the megapollycultural world of THS into a monoculture is a classic cyberpunk theme.

Having the mechanics of the Alcubierre Drive basically solved and several models of warp ship exploring the nearby stars would also make a great campaign.

Give us some of your ideas.