Quote:
Originally Posted by cptbutton
As above, you have to go through puberty again. Or menopause...
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These were the first things that leaped out at me. Well any sort of hormonal imbalance really.
Sudden weight gains or losses, heightened or reduced libido, lethargy ect are easyly gameable effects with immediate relevance. They are also fairly plausible for a drug making system wide changes.
The other option is low level neurological effects. For example changing or suppressing the sense of taste and smell.