How do you handle Affliction: Destiny?

[David Johansen]

In the later Dune books "The Atredies Manifesto" puts forward the idea that prescience actually imposes a future on the universe rather than seeing it. The Sister Superior of the Bene Gessert is firmly of the belief that the spark of Leto II's consciousness in the new sand worms is actually holding humanity to his golden path even after his death.

So, very large area effect Affliction: Destiny.