Re: Modern Horror/Action/Secret Fantasy in Boston
This setting is GURPS Cabal: Ken Hite has already done all the heavy lifting for you. I'd simply use his work.
That said: if vampires exist and you want your setting to be plausible, they operate under draconian rules of secrecy. They are likely diverting from the massive unregulated US and Chinese blood markets rather than feeding directly. A little googling on this yields fascinating reading btw.
No combination of uneasily coexisting supernatural conspiracies could long remain undiscovered in today's world without some sort of overarching treaty, ruthlessly enforced. In my Cabal campaign, the PCs are those enforcers - supernatural beings charged by the Grand Masters with keeping the Secret and tracking down rogue agents. Stealing an idea from Nightwatch, their 'police' units are divided by the hours of light and darkness: Ordo Lux and Ordo Tenebris, two sides of the same coin charged with the same mission, but serving different Masters.
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