Afflictions for wizards

[DeadParrot]

A bacteriological version of the FML mentioned above. When first infected, the wizard would notice no difference as the number of bacteria is too small. Each time the wizard successfully casts a spell, the bacteria steal enough energy to divide once. At some point, there are enough bacteria that they steal all of the energy the wizard tries to put into a spell.

Up to the GM to determine how many generations of bacteria are needed to dampen spell attempts. Might be days, or even months if the wizard doesn't cast that many spells, before the wizard notices the drain.

Cure might involve rare materials or simply starving the bacteria by the wizard abstaining from magic use for some number of days or months. Maybe putting the wizard in a suit of full iron plate to prevent magic.

For more mundane problems:
Bad vision would prevent precise targeting of spells.
Loss of hearing might interfere with spells that have a spoken component.
Developing an allergy to silver.
What do you do with a drunken Wizard?