Jet + Respiratory Agent

[Bilanthri]

I'm designing a set of short-ranged attacks meant to deliver a chemical respiratory agent on the breath of the user.

Breath Attack (+50%)
Jet, 0%; Respiratory Agent, 50%; No Signature, 20%; Reduced Range 5, -20%.

My question is: Does the user need to target the face with an attack like this, or would hitting center of mass leave the victim susceptible as long as they don't hold their breath?

It seems to me that the enhancement of Respiratory Agent would be diminished by the -5 to hit the face, and so not much of an enhancement after all.

And I know that Cone would be a simpler resolution, but I prefer this particular attack to be single-target.