Curse Priority

[tremorlaine]

In the first scenario your friend is dead. He cannot play any other cards unless they specifically allow him to cancel the Curse.

In your second scenario, your hand is discarded. Since cards are carried out to completion before another card can be played (unless the card allows you to cancel the effects of what just happened to you) you could not Curse anyone else. Those Curses go to the discard as well.