Lose an item

[MunchkinMan]

Originally Posted by snarky

If it says "Lose an Item", it must be a card that is in play.

If it says "Discard a Card", then it may come from in play OR in your hand.

(I think)

You think correctly. The rules should say something along the lines that if a card is in your hand, it doesn't count as anything, so if something refers to a Race or Class or Item, and so on, it must be in play to count.