[Phantasm]

I've also played TSR's Marvel Super-Heroes Advanced Set and Mayfair's DC Heroes 5e (or whichever version was the "Death and Life of Superman" era)

TSR Marvel Super-Heroes: Pros: Good, flexible system for character creation, able to handle Aunt May through Eternity, and everything in-between (including the In-Betweener). Scales decently between "mundane" and "cosmic" level characters. The Advanced Set answered some issues from the original Basic Set on cosmic-scale characters and reworked Resources from a points-based system to a stat check system. Cons: Does not work as neatly in combat as it could.

Mayfair DC Heroes: Its exponential stat scaling may fit the comics (though Superman having a strength score enabling him to bench-press 9 to 12 digits of tons broke my suspension of disbelief), but everything wound up far too abstract in practice, IMO.


EDIT: ninjaed on the TSR Marvel game....