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Originally Posted by Johnny1A.2
Excellent question. Your guess is just as good as anyone else's, including the space medics, because we literally have almost no data on which to make an evaluation.
OTOH, when it comes to the effects of gravity when present but not at 1G, we have a tiny sampliing of short-term data at 1/6 G, from the Apollo missions, and...well, that's pretty much all we have.
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Originally Posted by Johnny1A.2
To be brutally realistic, the most likely optimal spot is probably 1G, because that's our native environment.
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Actually there is a series of experiments where chickens were raised in higher G environments in centrifuges. This was long term, several chicken generations. One of the chapters in
Great Mambo Chicken and the Transhuman Condition has the data from this. They ended up healthier and longer lived than regular chickens.
Still very few data points. You could replicate the centrifuge experiment with small mammals to see if they react differently from birds fairly easily but less than 1 G but not 0 requires putting a large centrifuge in orbit.