[AlexanderHowl]

Well, other religions would have other deities, depending on their native alchemical tradition. It could be that every alchemical potion is associated with a specific deity (or every alchemical Path if using an alchemical version of RPM), so alchemical potions would have different sanctity. In any case, sanctity-based alchemy would be effective in no mana worlds.

An interesting idea would be having sanctity-based alchemical RPM (Alchemy being the core skill) and sanctity-based herbal RPM (Herb Lore being the core skill). In the former case, urban areas would be high sanctity and wilderness areas would be low sanctity. In the latter case, wilderness areas would be high sanity and urban areas would be low sanctity.