[Phantasm]

I've used Social Disease to represent someone HIV-positive in the '80s and '90s (guy was a heroin-addicted womanizer, no less), and to represent someone in the Age of Sail with syphilis. (Both in the "we have no cures, and treatments are few and far between" time frames for those diseases.)

Both times, I wasn't sure how else to represent having these diseases, or how the effects would play out in the game world. As a "catch-all" for covering all possible effects of these diseases, it worked as a placeholder until the characters could - if possible - be respecced to fit how the world reacted to them better.