[Varyon]

Cyberpunk isn't really compatible with a hopeful setting of exploring strange new worlds, seeking out new life and new civilizations, and boldly going where no man has gone before. Cyberpunk is, rather, all about being a rebel (hence the "punk") in a world controlled by corrupt corporations, for whom money and power are basically all that matter.

Cyberpunk is compatible with a space setting. But it would likely be one where essentially every colony, station, etc are under the control of one or more megacorporations (there's room for "pirate colonies" and the like, but these are going to be the functional equivalent of slums/shantytowns, and in many cases the megacorps will have their claws in the power structure in some way). Habitable-but-not-yet-inhabited planets will have already been claimed by the megacorps. New civilizations would either be primitive and quickly subjugated by the megacorps, or themselves already be cyberpunk-style dystopias that can be readily integrated into the existing society, adding some new megacorps into the mix.

If that doesn't sound like what you want, then I'd say you're probably looking for something of a transhuman setting rather than a cyperpunk one. You don't have to go as all-in as THS - maybe the human mind is too complex - and/or too integrated into its existing hardware - to be able to just do mind transfers, so you can't hop from one shell to another... but you can upgrade the body you're already in.