I thought of one in which characters played experimental uplifted raccoons who escape from a bio-research lab, conducting some work on behalf of a corporate client interested in making new companions for all sorts of human support markets.
I went with a breakthrough in intelligence that boosted them to human average (IQ 10), instead of the borderline IQ 5-8, which the sponsoring corporation considered a negative development. That had triggered some debate amongst the researchers about what to do with the, "Nova-coon" uplifts.
The PCs would play nova-coon uplifts who learn of the debate, and realize they need to take their fate into their own (quite dexterous) hands, escape the lab with as many of their companions as possible, and try to remain hidden while they find a haven.
It's very much derived from the original book,
Mrs. Frisby and the Rats of NIMH,
https://en.wikipedia.org/wiki/Mrs._F...e_Rats_of_NIMH, but not so much from the Disney version.
I never got much further than just the premise, though.