[alexondria]

You can definitely do different themes.

Afterlife: In canon devoted pagans can end up in the ethereal realms of the god they followed.

My most successful game started with Fall of the Malakite and took a hard left out of canon. The rough theme of my game was a group of Angels and Demons that had to work together for trumped up reasons discovering that both Heaven and Hell had lost sight of what they were fighting for. Demons had started fighting the noble fight for freedom and free will. Angels had started fighting the noble fight for justice and compassion. Sadly at the current point in history they'd both lost sight of that and were just fighting to win. Demons were torturing souls for essence. Angels were allowing killing they should have stopped because it was for the greater good. The party actually ended up rallying the ethereals with Isis to force a new power structure for humanities benefit.