[Kale]

Normal knife tactics target the limbs and vital points, and tends to focus on protecting against your own knife being taken away from you. Supernatural threats would probably need training on tactics for exposing and attacking vital points on specific monsters, and how to avoid counterattacks of specific monsters in close combat. If certain monsters treat various metals or chemicals as poisons then knife throwing may also be a useful secondary skill to keep your foe at some distance. This assumes you actually carry a brace of throwing knives or similar as backup for a proper non-throwing knife.
Also consider hatchets, which while not as portable, provide solid cutting damage which can be useful for some threats, and are still throwable in a pinch.