Disadvantage - gigantism and interactions with other genetic anomalities

Solomon Draak · 02-02-2023, 12:21 PM

So.
As we know by following the incredible life of Andre the Giant, most athletes and wrestlers who owned their size to gigantism suffered intense pain throughout their body as they got older. Many, like Andre, died of congestive heart failure. Yet the main problem faced by the giant was the weakening of his joints, leading him to break his ankle just by slightly twisting it.

Now. There is a genetic anomaly, that mabye inspired the film Unbreakable ( with Bruce Willis, year 2000 ) that produces incredibly high bone density and almost indestructible skeletons ( LRP5 gene mutation ).

So.
Thought exercise: if someone suffering from acromegaly, like Andre, also had the mixed blessing of ultra-dense bones due LRP5 mutation, could he benefit from this combination? Would he suffer less - or not at all - from joint and spine weakening?

And, if we add in the mix a myostatin-related anomaly ( genetic induced muscle hypertrophy ) could the increased muscle mass and reduced adipose mass help the giant to sustain his own weight?

02-02-2023, 12:21 PM	#1
Solomon Draak Join Date: Jan 2023	Disadvantage - gigantism and interactions with other genetic anomalities So. As we know by following the incredible life of Andre the Giant, most athletes and wrestlers who owned their size to gigantism suffered intense pain throughout their body as they got older. Many, like Andre, died of congestive heart failure. Yet the main problem faced by the giant was the weakening of his joints, leading him to break his ankle just by slightly twisting it. Now. There is a genetic anomaly, that mabye inspired the film Unbreakable ( with Bruce Willis, year 2000 ) that produces incredibly high bone density and almost indestructible skeletons ( LRP5 gene mutation ). So. Thought exercise: if someone suffering from acromegaly, like Andre, also had the mixed blessing of ultra-dense bones due LRP5 mutation, could he benefit from this combination? Would he suffer less - or not at all - from joint and spine weakening? And, if we add in the mix a myostatin-related anomaly ( genetic induced muscle hypertrophy ) could the increased muscle mass and reduced adipose mass help the giant to sustain his own weight?