Re: Assassination a la Sam Fisher
They have no defence, so you can telegraphic for a free +4. Even if they don't they will probably still have shock etc, so you can reasonably safely all-out.
Stab them in the vitals, or swing for the neck. Or do AOO Double and hit both, if your skill is slightly higher. If you're a good fighter with high skill, bonuses to rapid strike and things like weapon master, you could easily get multiple hits to important and un/lightly armoured areas.
If you're taking them un-armed then it's going to be harder, I'd probably go for AOO double, first attack to grapple, second to do a neck snap.
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