[Refplace]

I ran a Supers campaign with a mix and Bio-ships were competitive because they could have Powewrs.
Never ran a Sci-fi game where they were alongside each other as equals. More weird alians you met on the frontier or forerunner craft.
However they could be competitive in some settings.
Easier to maintain and more self sufficient is one option but they also could be good for long term planning where you seed them and then they do their mission or you come back to harvest years, decades or even centuries later.
In Magic or psi settings they could have another possible edge.