[Humabout]

I've used Total Amnesia as a mandatory disadvantage to intro into a game (with some very trusting players). They woke up in a strange facility and had to use clues on their persons to sort out who they were, and they had a lot of fun discovering their identities while dealing with the effects of a government black site experiment and conspiracy.

It was also the first time I saw anyone with Contact Group (Conspiracy Forum).

As for play, the players were great at falling into a group and working together to survive and figure out who they were. They also knew going in they'd all have amnesia and were cool with not making their own sheets. I think they wanted the challenge of rooeplaying random PCs.