[Clipper]

I've played a full Fantasy deck with new players and while most seemed to have enjoyed it, it didn't really go nearly as well as initiation games I've played with just base sets or sets with a single expansion. I'd definitely recommend to not use Demented Dungeons until your players have played a few games to get used to the normal rules. I'd also leave out Cheat With Both Hands with beginners as many of the cards rely on advanced features, like the Epic rules. The licensed boosters (Penny Arcade, The Guild, etc.) definitely work well if you have some fans of the various properties at the table and they don't upset the learning curve too much, so I would recommend starting with those.