I did it a few times as GM.
In Shadowrun, I reused the plot of "Narrow Margin", only aboard a maglev train that drove through Germany with 300 kph. The witness had to make a statement before the highest German Court.
https://en.wikipedia.org/wiki/Narrow_Margin
And in our old Gurps Traveller campaign, the captain of the free trader was hired to deliver a sealed suitcase to an unknown recipient. Who turned out to be the Duchess of Glisten. Inside the suitcase was a 3.500 year old Batman Comic Book for her library.