[Clipper]

I'm not sure it would work too well. Before trying anything else, your best bet would be to try playing a game using the base Munchkin cards rather than the Quest cards. I suspect your monsters won't work too well as they aren't designed to give you hits and many of the rooms would never translate as you don't have keywords on the Items. You won't have Healing Potions to recover the hits you get from losing battles and you lose all the d10 powers on Classes (or would need to think of some new ones). While it might work, I doubt it would be balanced enough to be fun.