I've done some work on this topic myself. Depending on the genre, you might be able to get down to fifty skills, but I think you would need to do what other games do and cheat by combining what are individual skills in GURPS into skills where you must choose to specialize. We already have that with the Games skill. You could have a Craft skill, a Science skill, etc. Further, you could compress all the melee weapon skills into a single skill.
If handling the different crafting skills in that way counts as reducing the list, then this is definitely possible. I don't think there's any way to shrink the list much more than I have while keeping a separate butchering and sewing skill, and all that entails.
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