To contribute a little to the thread:
Lost Girl. While the setting is not terribly original, it is detailed enough to work as campaign backdrop, but not so set in stone as to make original content difficult. For example, the main characters are (as of the first season) not so central to the setting that
everything revolves around them.
Defiance also has an interesting setting, with multiple races with distinct cultures and a schizo-tech post-apocalyptic world that allows for everything from political intrigue to treasure hunting.