[vicky_molokh]

Q: Fatigue attacks ignore hit location. What exactly does that mean?
A:

Originally Posted by Kromm

The cited rule means that attacks that cause FP are subject to no special wounding effects for hit location. You can pick any body part on your target and attack it at the usual penalty for hit location. If the target has FP, then the attack reduces those FP by the amount rolled minus any DR on the body part, unless the attack happens to ignore DR (not an intrinsic property of attacks with the fat damage type). The only limit on how many FP can be caused is the target's usual floor of -FP.

In much shorter terms, it's mostly a statement that you can't get bonus FP by aiming at the skull or vitals, and don't inflict fewer FP just because you hit a hand or an arm.